Table 4 The adjusted risks for rapid eGFR decline (eGFR decline > 3 ml/min/1.73 m2/year) within 1 year prior to questionnaire examination in study patients stratified by age according to self-care behavior and disease knowledge scores.

From: The interaction between self-care behavior and disease knowledge on the decline in renal function in chronic kidney disease

 

Age ≥ median (67 years)

Age < median (67 years)

Percentage of eGFR decline > 3 ml/min/1.73 m2/year

Rapid eGFR decline

Percentage of eGFR decline > 3 ml/min/1.73 m2/year

Rapid eGFR decline

Adjusted odds ratio (95% Cl)

p-value

Adjusted odds ratio (95% Cl)

p-value

Self-care behavior (per score)

67/227 (29.5)

0.97 (0.94–1.00)

0.07

80/227 (35.2)

0.97 (0.94–0.99)

0.02

Self-care behavior (quartiles)

Quartile 1

20/51 (39.2)

Reference

 

33/74 (44.6)

Reference

 

Quartile 2

14/45 (31.1)

0.65 (0.27–1.55)

0.3

23/62 (37.1)

0.80 (0.39–1.66)

0.6

Quartile 3

22/76 (28.9)

0.66 (0.30–1.44)

0.3

13/50 (26.0)

0.48 (0.21–1.09)

0.07

Quartile 4

11/55 (20.0)

0.39 (0.16–0.93)

0.03

11/41 (26.8)

0.42 (0.17–1.00)

0.05

Disease knowledge (per score)

67/227 (29.5)

0.96 (0.90–1.01)

0.1

80/227 (35.2)

0.86 (0.81–0.92)

 < 0.001

Disease knowledge (quartiles)

Quartile 1

34/93 (36.6)

Reference

 

25/45 (55.6)

Reference

 

Quartile 2

10/43 (23.3)

0.59 (0.25–1.36)

0.2

22/47 (46.8)

0.91 (0.37–2.22)

0.8

Quartile 3

15/56 (26.8)

0.69 (0.32–1.49)

0.4

18/64 (28.1)

0.30 (0.13–0.70)

0.006

Quartile 4

8/35 (22.9)

0.61 (0.24–1.55)

0.3

15/71 (21.1)

0.19 (0.08–0.46)

 < 0.001

Interaction between self-care score and disease knowledge score

67/227 (29.5)

0.99 (0.99–1.00)

0.04

80/227 (35.2)

0.99 (0.99–0.99)

 < 0.001

Low self-care score and low disease knowledge score

24/67 (35.8)

Reference

 

34/66 (51.5)

Reference

 

High self-care score and low disease knowledge score

20/69 (29.0)

0.78 (0.37–1.64)

0.5

13/26 (50.0)

1.09 (0.41–2.86)

0.8

Low self-care score and high disease knowledge score

10/29 (34.5)

1.07 (0.41–2.80)

0.9

22/70 (31.4)

0.37 (0.17–0.78)

0.009

High self-care score and high disease knowledge score

13/62 (21.0)

0.55 (0.24–1.23)

0.1

11/65 (16.9)

0.16 (0.07–0.39)

 < 0.001

  1. Adjusted model of self-care behavior and disease knowledge in rapid eGFR decline included age, sex and all variables in Table 1 whose p-value were < 0.05 including diabetes mellitus, hemoglobin, baseline estimated glomerular filtration rate, and log-formed urine protein-creatinine ratio in unadjusted model.
  2. Self-care score quartile cut at 59, 67 and 72.
  3. Disease knowledge score quartile cut at 18, 22 and 25.
  4. Low self-care as less than median of self-care score; high self-care as above median of self-care score.
  5. Low disease knowledge as less than median of disease knowledge score; High disease knowledge as above median of disease knowledge score.
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