Table 2 Demographic characteristics of the IMPROVE participants, by cluster (MAF > 10%).

From: The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals

 

1

2

3

P**

N

1222 (36.2)

1629 (48.2)

526 (15.6)

 

Men (%)

581 (47.6)

842 (51.7)

268 (51.0)

0.954

Age (years)

64.2 (5.4)

64.2 (5.4)

64.4 (5.4)

0.558

BMI (kg/m2)

27.4 (4.3)

27.2 (4.2)

27.0 (4.2)

0.259

Waist (cm)

94.5 (12.8)

93.8 (12.4)

93.9 (12.6)

0.298

Waist_hip

0.92 (0.09)

0.92 (0.09)

0.94 (12.6)

0.859

SBP (mmHg)

142 (18)

142 (19)

140 (18)

0.070

DBP (mmHg)

82 (10)

82 (10)

82 (10)

0.599

HTN

982 (80.4)

1321 (81.1)

389 (74.0)

0.004

HTN medication

694 (56.8)

805 (58.1)

291 (55.3)

0.421

SBP* (mmHg)*

151 (20)

151 (21)

148 (21)

0.080

DBP* (mmHg)*

88 (11)

88 (11)

87 (12)

0.368

NSAIDs

253 (20.7)

260 (18.8)

102 (19.4)

0.622

Current smoking

172 (14.1)

246 (15.1)

87 (16.5)

0.614

Pack years

10.7 (17.2)

10.7 (15.9)

12.3 (19.7)

0.191

T2D

342 (28.0)

414 (25.4)

145 (27.6)

0.252

Lipid-lowering medication

585 (47.9)

828 (50.9)

256 (48.8)

0.159

Framingham risk score

0.27 (0.16)

0.27 (0.16)

0.27 (0.16)

0.743

Cardiac event

74 (6.1)

94 (5.8)

22 (4.2)

0.208

Baseline

CC-IMTmean

0.740 (0.130)

0.745 (0.147)

0.749 (0.155)

0.962

IMTmean

0.895 (0.198)

0.888 (0.199)

0.888 (0.205)

0.296

CC-IMTmax

1.184 (0.368)

1.197 (0.400)

1.222 (0.456)

0.705

IMTmax

2.051 (0.812)

2.026 (0.803)

2.040 (0.849)

0.502

IMTmeanmax

1.258 (0.295)

1.252 (0.298)

1.247 (0.306)

0.300

Diameter

7.847 (0.854)

7.834 (0.862)

7.796 (0.839)

0.441

Progression

CC-IMTmean

0.009 (0.029)

0.009 (0.027)

0.006 (0.026)

0.193

IMTmean

0.019 (0.032)

0.019 (0.032)

0.017 (0.033)

0.508

CC-IMTmax

0.016 (0.096)

0.017 (0.093)

0.007 (0.098)

0.281

IMTmax

0.049 (0.164)

0.042 (0.156)

0.035 (0.178)

0.209

IMTmeanmax

0.026 (0.053)

0.026 (0.051)

0.023 (0.054)

0.240

IMTfastest

0.176 (0.149)

0.166 (0.139)

0.156 (0.147)

0.002

Diameter

0.003 (0.030)

0.005 (0.033)

0.003 (0.029)

0.749

  1. Highlighted in bold are the significant (p < 0.05) differences between groups.
  2. Where: *, adjusted to provide estimates of treatment-naïve levels as per Ehret et al.; Statistical analyses compared levels or frequncies across groups 1, 2 and 3. Ungrouped (.) were omitted from the analyses). **P for Pearsons chi square for categorical variables and Kruskal–Wallis for continuous variables; na, not available.
Back to article page