Table 1 Overall Tamoxifen enzymatic activity groups according to CYP2D6 and CYP2C19 genotypes.
From: Effect of CYP2C19 genotypes on tamoxifen metabolism and early-breast cancer relapse
CYP2D6* | CYP2C19 | |
|---|---|---|
Activity groups according to CYP2D6 and CYP2C19 genotypes | ||
High activity | EM/EM | *17/*17; *1/*17 |
Intermediate activity | EM/EM | *1/*1; *1/*2; *2/*2; *2/*17 |
EM/IM | *1/*1; *1/*17; *17/*17; *2/*17 | |
EM/PM | *1/*1; *1/*17; *17/*17; *2/*17 | |
Low activity | EM/IM | *1/*2; *2/*2 |
EM/PM | *1/*2; *2/*2 | |
IM/IM | *1/*1; *1/*2; *2/*2; *1/*17; *17/*17; *2/*17 | |
IM/PM | *1/*1; *1/*2; *2/*2; *1/*17; *17/*17; *2/*17 | |
PM/PM | *1/*1; *1/*2; *2/*2; *1/*17; *17/*17; *2/*17 | |
