Figure 6

Schematic diagram of enhanced viral production and anti-tumoral effect by a combination of Daxx downregulation, and pTP upregulation, in E1B55K/19K deleted oncolytic adenovirus. pTP upregulation greatly increased viral production, while Daxx downregulation increased mainly infectivity, but not total virus particles. Additionally, Daxx downregulation induced stronger apoptotic cell death than pTP expression did in tumor cells with wild type p53, resulting in an enhanced anti-tumoral effect. This suggests that the combination of both Daxx downregulation and pTP upregulation in oncolytic adenovirus therapy could be an ideal cooperative pairing.