Figure 1
From: NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization
Interaction between NPMmut and C21 point mutants. (a) Left: localization of R_NPMwt/C21A/C21F in single transfected 293T cells. Right: 293T cells co-transfected with G_NPMmut (green) and R_NPMwt/C21A/C21F variants (red). Red signal in the cytoplasm and green signal in nucleoli witness for an interaction between NPMmut and NPMwt/C21A/C21F. (b) Statistical evaluation of the subcellular localization of NPMwt and C21 mutants. Fraction of transfected 293T cells displaying red signal from the cytoplasm in single transfected cells (left group) and in cells co-transfected with G_NPMmut (right group). Error bars represent ± SD of at least 3 independent experiments, p < 0.0001 (****) for the differences between the co-transfected and the single-transfected cells.
