Figure 1
Summary of regression analysis for RNA-seq. (A) Volcano plot of DEGs. Positive log fold change corresponds to increased expression in ethanol-treated organoids. (B) MA plot highlighting differential expression in left colon (left panel) and right colon organoids (right panel) in response to ethanol. Orange values indicate significance. Positive log fold change corresponds to increased expression in vehicle control organoids. (C) Test-statistics generated from each colon location (left panel) and sex (right panel) subsets were correlated (spearman rank) to each other. (D) Stratified analysis by colon location and sex revealed that a greater number of nominal DEGs were identified in male, left colon organoids than any other subset.
