Figure 2

Areas of gray matter volume that showed childhood maltreatment by FH+ subgroups (FH+DEP−, FH+DEP+) interaction. (A) Axial-oblique images show regional gray matter volume (GMV) that showed a significant family history positive (FH+) subgroup by Childhood Trauma Questionnaire (CTQ) total score interaction. Higher CTQ score correlated with lower GMV in FH+ individuals with a history of unipolar depression (FH+DEP+), and conversely, greater GMV, or no significant relation, in these clusters in FH+ individuals without a history of unipolar depression (FH+DEP−). Total N = 21; FH+DEP−: N = 9; FH+DEP+: N = 12. (B) Axial-oblique images show regional GMV that showed a significant bipolar disorder FH+ subgroup by CTQ total score interaction when removing the four individuals with highest CTQ scores in the FH+DEP+ subgroup so groups were matched on total CTQ scores. Higher CTQ score was related to lower GMV in FH+DEP+ individuals, and conversely, greater GMV, or no significant relation, in these clusters in FH+DEP− individuals. Total N = 17; FH+DEP−: N = 9; FH+DEP+: N = 8). Significance threshold is p < 0.005, uncorrected; clusters > 20 voxels. Left of figure denotes left side of brain. Color bar represents range of T values.