Table 4 Areas of gray matter volume showing a significant FH+ subgroup (FH+DEP− vs. FH+DEP+) by Childhood Trauma Questionnaire total score interaction.

From: Childhood maltreatment, prefrontal-paralimbic gray matter volume, and substance use in young adults and interactions with risk for bipolar disorder

	Cluster localization and MNI coordinates at cluster peak	FH+DEP− (N = 9)			FH+DEP+(N = 12)
	Cluster localization and MNI coordinates at cluster peak	t Ratio	SE	p-value	t Ratio	SE	p-value
Ventral prefrontal cortex	Left Brodmann Area 11 x = − 18 mm, y = 23 mm, z = − 21 mm, clusters = 21 voxels	3.16	0.002	0.02	− 3.45	0.0005	0.007
		F_(2,8) = 5.0, p = 0.05, R² = 0.6			F_(2,11) = 13.0, p = 0.002, R² = 0.7
	Left Brodmann Area 11 x = − 15 mm, y = 11 mm, z = − 15 mm, clusters = 81 voxels	2.9	0.001	0.03	− 3.6	0.0005	0.006
		F_(2,8) = 4.8, p = 0.06, R² = 0.6			F_(2,11) = 7.2, p = 0.01, R² = 0.6
	Left Brodmann Area 47 x = − 44 mm, y = 42 mm, z = − 14 mm, clusters = 295 voxels	3.9	0.001	0.008	− 5.0	0.0005	0.008
		F_(2,8) = 8.4, p = 0.02, R² = 0.7			F_(2,11) = 12.4, p = 0.003, R² = 0.7
	Right Brodmann Area 11 x = 5 mm, y = 50 mm, z = − 18 mm, clusters = 26 voxels	2.2	0.001	0.07	− 4.9	0.0005	0.0008
		F_(2,8) = 3.5, p = 0.1, R² = 0.5			F_(2,11) = 12.3, p = 0.003, R² = 0.7
	Right Brodmann Area 11 x = 9 mm, y = 12 mm, z = − 14 mm, clusters = 23 voxels	1.8	0.001	0.12	− 4.6	0.0006	0.001
		F_(2,8) = 1.6, p = 0.3, R² = 0.3			F_(2,11) = 11.3, p = 0.004, R² = 0.7
	Right Brodmann Area 47 x = 41 mm, y = 27 mm, z = − 5 mm, clusters = 67 voxels	2.4	0.001	0.05	− 5.5	0.0007	0.0004
		F_(2,8) = 2.9, p = 0.1, R² = 0.5			F_(2,11) = 15.6, p = 0.001, R² = 0.8
Rostral and dorsal prefrontal cortex	Left Brodmann Area 10 x = − 12 mm, y = 62 mm, z = − 8 mm, clusters = 110 voxels	5.11	0.0006	0.002	− 5.7	0.0004	0.0003
		F_(2,8) = 18.2, p = 0.003, R² = 0.9			F_(2,11) = 18.2, p = 0.0007, R² = 0.8
	Left Brodmann Area 10 x = − 17 mm, y = 48 mm, z = 14 mm, clusters = 34 voxels	3.4	0.001	0.02	− 2.4	0.0004	0.04
		F_(2,8) = 5.7, p = 0.04, R² = 0.7			F_(2,11) = 4.7, p = 0.04, R² = 0.5
	Right Brodmann Area 10 x = 39 mm, y = 47 mm, z = − 12 mm, clusters = 20 voxels	2.9	0.001	0.03	− 3.2	0.0007	0.01
		F_(2,8) = 4.1, p = 0.08, R² = 0.6			F_(2,11) = 5.2, p = 0.03, R² = 0.5
	Right Brodmann Area 46 x = 50 mm, y = 38 mm, z = 9 mm, clusters = 444 voxels	2.9	0.002	0.03	− 4.8	0.0007	0.001
		F_(2,8) = 5.4, p = 0.05, R² = 0.6			F_(2,11) = 12.0, p = 0.003, R² = 0.7
	Right Brodmann Area 10 x = 9 mm, y = 60 mm, z = 17 mm, clusters = 70 voxels	2.1	0.002	0.09	− 4.4	0.0005	0.002
		F_(2,8) = 2.8, p = 0.1, R² = 0.5			F_(2,11) = 10.7, p = 0.004, R² = 0.7
Insula	Left Insula x = − 44 mm, y = 6 mm, z = 8 mm, clusters = 864 voxels	3.1	0.002	0.02	− 3.9	0.0008	0.003
		F_(2,8) = 4.7, p = 0.06, R² = 0.6			F_(2,11) = 7.8, p = 0.01, R² = 0.6
	Right Insula x = 36 mm, y = 17 mm, z = − 6 mm, clusters = 77 voxels	2.7	0.001	0.04	− 4.0	0.0008	0.003
		F_(2,8) = 3.6, p = 0.09, R² = 0.5			F_(2,11) = 8.8, p = 0.009, R² = 0.6

Brodmann Area and Montreal Neurological Institute space coordinates for clusters showing a significant FH+ subgroup by Childhood Trauma Questionnaire (CTQ) total score interaction. Using extracted gray matter volume (GMV) from these clusters, relations between CTQ total score and extracted GMV were modeled stratified by bipolar disorder family history positive (FH+) subgroups [FH+ individuals without a history of unipolar depression (FH+DEP−); FH+ individuals with a history of unipolar depression (FH+DEP+)] while covarying biological sex. Results are reported for the overall model for each cluster, and the GMV factor within each model for each cluster.

Back to article page

Table 4 Areas of gray matter volume showing a significant FH+ subgroup (FH+DEP− vs. FH+DEP+) by Childhood Trauma Questionnaire total score interaction.

Search

Quick links