Table 2 Orthologs identified in the Rhipicephalus evertsi evertsi transcriptome for proteins with known functions.

From: De novo assembled salivary gland transcriptome and expression pattern analyses for Rhipicephalus evertsi evertsi Neuman, 1897 male and female ticks

Protein

Function

Protein family

Orthologs in transcriptome

References

Apyrase*

ATP/ADP hydrolysis

5′-nucleotidase

Reve10069, Reve7259, Reve53772, Reve29549, Reve67417

111

Aas19

Platelet aggregation; Thrombin

Serpin

Reve9044

60,112

AaS27

Inflammation; fXIa

Serpin

Reve68878

113

IRS-2

Cathepsin-G

Serpin

Reve68878

114

Amblin

Thrombin

Kunitz

Reve18091, Reve25119

54

Boophilin

Thrombin

Kunitz

Reve26164, Reve34404, Reve25119

56

Rhipilin 1

Anticoagulant

Kunitz

Reve1377, Reve53258,

115

Rhipilin 2

Elastase

Kunitz

Reve35686

116

Longistatin*

Plasminogen activator

EF-hand

Reve56956, Reve37845

64

Enolase

Plasminogen receptor

 

Reve2489

117

IsMP

Fibin(ogen)olytic

Metalloprotease

Reve2893

46

Iris

Hemostasis

Serpin

Reve33028

118

HBP1*

Histamine

Lipocalin

Reve4256, Reve4504, Reve17348, Reve9406

51

EvasinB

Chemokines

Knottin

Reve23059

119

Histamine release factor

Vascular permeability

Translationally controlled tumor protein (TCTP)

Reve6137

120,121

IGBPA

IgG binding

 

Reve12277

37

IGBPC

IgG binding

 

Reve43878, Reve19418

37

Angiotensin converting enzyme*

Bradykinin

 

Reve50087, Reve2424, Reve60442

49

CirPT1

Complement C5

Von Willebrandt factor type C

Reve_16140, Reve18664, Reve62569, Reve34768

52

RmS-15

Thrombin

Serpin

Reve9044

61

EVA-P991

Chemokines

Evasin A

Reve41657

122

  1. Those proteins with asterisks are considered orthologous to ancestral tick lineages of platelet aggregation inhibitors, blood clotting inhibitors and immune-modulators26. Orthologs were confirmed by phylogenetic analysis and were included if the homologs grouped within a well-defined orthologous clade with good bootstrap support that included the sequence with experimental confirmed function.