Table 1 The main characteristics of real cells and their phantoms.
From: Dynamic blood flow phantom for in vivo liquid biopsy standardization
Target type | Target compartment | Material | Shape | Diameter, µm | Average melanin content, pg/object | Coefficient of absorption curve slope | Absorption at 980 nm wavelength, a.u. |
|---|---|---|---|---|---|---|---|
B16F10 cells | Natural melanin | – | Spherical in an unattached state (circulating in blood) | 13.4 ± 4.3 | 2.5 ± 0.546 | − 0.0031 | 0.95 |
Melanoma phantoms | Melanin from Sepia Officinalis | Polymers | Spherical | 12 ± 3 | 12.6 ± 0.3 | − 0.0027 | 1.05 |
|  | Target compartment | Material | Shape | Diameter, µm | Height of absorption peak at 540 nm, a.u. | Height of absorption peak at 570 nm, a.u. | Average RMS amplitude of PA signal, a.u. |
RBCs | Hemoglobin | - | Spherical | 6.9 ± 0.6 | 0.035 | 0.044 | 0.35–0.55 |
RBC phantom | Hemoglobin | Silica | Spherical | 3.07 ± 0.76 | 0.043 | 0.038 | 0.138 |
|  | Target compartment | Material | Shape | Diameter, µm | – | – | – |
WBCs | – | – | Spherical | 7.6 ± 0.5 | – | – | – |
WBC phantom | – | Silica | Spherical | 5.4 ± 0.6 | – | – | – |
|  | Target compartment | Material | Shape | Diameter, µm | – | – | – |
Platelets | – | – | Spherical | 1.7 ± 0.3 | – | – | – |
Platelet phantom | – | Silica | Spherical | 1.1 ± 0.3 | – | – | – |
