Table 1 Proportion of hubs and bottlenecks in human proteins based on their interactions with bacterial pathogens.
Pathogen interaction status | Total proteins | Hubs | % Hubs | Mean interacting partners | Significance |
|---|---|---|---|---|---|
Proportion of Hubs in pathogen-interacting and non-interacting human proteins | |||||
Non-interacting | 9137 | 1498 | 16.39 | 8.95 | P%Hubs = 6.12 × 10─65, Fisher’s exact test; PMean_Interaction_Partner = 5.09 × 10─92, Kruskal–Wallis test |
Interacting with one | 1802 | 468 | 25.97 | 12.82 | |
Interacting with two | 635 | 250 | 39.37 | 18.07 | |
Interacting with three | 241 | 101 | 41.91 | 23.84 | |
Pathogen interaction status | Total proteins | Bottlenecks | %Bottlenecks | Significance | |
|---|---|---|---|---|---|
Proportion of Bottlenecks in pathogen-interacting and non-interacting human proteins | |||||
Non-interacting | 9137 | 1540 | 16.85 | P%Bottleneck = 1.96 × 10─58, Fisher’s exact test | |
Interacting with one | 1802 | 477 | 26.47 | ||
Interacting with two | 635 | 235 | 37.01 | ||
Interacting with three | 241 | 105 | 43.57 | ||
