Table 3 Reactome pathway enrichment analysis results for protein Lag 1 aggregate results for \(\hbox {TF}\Delta\) and TFD (top 20 pathways based on FDR for each time frame shown).
From: Longitudinal saliva omics responses to immune perturbation: a case study
Reactome pathway | Matched IDs | p value | FDR |
---|---|---|---|
A. Total saliva protein: TF\(\Delta\) | |||
Neutrophil degranulation | 96 | \(1.1\times 10^{-16}\) | \(6.8\times 10^{-14}\) |
Innate immune system | 135 | \(1.1\times 10^{-16}\) | \(6.8\times 10^{-14}\) |
Immune system | 158 | \(1.4\times 10^{-15}\) | \(5.9\times 10^{-13}\) |
Signaling by ROBO receptors | 34 | \(1.2\times 10^{-13}\) | \(3.8\times 10^{-11}\) |
Regulation of expression of SLITs and ROBOs | 29 | \(9.5\times 10^{-13}\) | \(2.3\times 10^{-10}\) |
Eukaryotic translation elongation | 22 | \(1.7\times 10^{-12}\) | \(3.5\times 10^{-10}\) |
Cellular responses to stress | 58 | \(3.3\times 10^{-12}\) | \(5.7\times 10^{-10}\) |
Cellular responses to external stimuli | 58 | \(9.0\times 10^{-12}\) | \(1.4\times 10^{-9}\) |
Peptide chain elongation | 20 | \(3.8\times 10^{-11}\) | \(5.2\times 10^{-9}\) |
Nonsense-mediated decay (NMD) | 22 | \(6.8\times 10^{-11}\) | \(7.5\times 10^{-9}\) |
Nonsense mediated decay (NMD) enhanced by the Exon Junction Complex (EJC) | 22 | \(6.8\times 10^{-11}\) | \(7.5\times 10^{-9}\) |
Nonsense mediated decay (NMD) independent of the exon junction complex (EJC) | 20 | \(7.7\times 10^{-11}\) | \(7.8\times 10^{-9}\) |
Eukaryotic translation termination | 20 | \(1.8\times 10^{-10}\) | \(1.7\times 10^{-8}\) |
SRP-dependent cotranslational protein targeting to membrane | 21 | \(2.0\times 10^{-10}\) | \(1.8\times 10^{-8}\) |
Viral mRNA translation | 20 | \(6.1\times 10^{-10}\) | \(4.9\times 10^{-8}\) |
Formation of a pool of free 40S subunits | 19 | \(1.2\times 10^{-9}\) | \(8.8\times 10^{-8}\) |
Platelet degranulation | 21 | \(2.4\times 10^{-9}\) | \(1.7\times 10^{-7}\) |
Selenocysteine synthesis | 19 | \(3.2\times 10^{-9}\) | \(2.2\times 10^{-7}\) |
Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs) | 20 | \(3.7\times 10^{-9}\) | \(2.4\times 10^{-7}\) |
Response of EIF2AK4 (GCN2) to amino acid deficiency | 19 | \(4.3\times 10^{-9}\) | \(2.6\times 10^{-7}\) |
B. Total saliva protein: TFD | |||
Eukaryotic translation elongation | 6 | \(3.5\times 10^{-7}\) | \(1.6\times 10^{-4}\) |
Nonsense-mediated decay (NMD) | 6 | \(1.1\times 10^{-6}\) | \(1.6\times 10^{-4}\) |
Nonsense mediated decay (NMD) enhanced by the exon junction complex (EJC) | 6 | \(1.1\times 10^{-6}\) | \(1.6\times 10^{-4}\) |
Signaling by ROBO receptors | 7 | \(3.2\times 10^{-6}\) | \(2.9\times 10^{-4}\) |
Translation | 8 | \(3.2\times 10^{-6}\) | \(2.9\times 10^{-4}\) |
Peptide chain elongation | 5 | \(6.9\times 10^{-6}\) | \(4.7\times 10^{-4}\) |
Nonsense mediated decay (NMD) independent of the exon junction complex (EJC) | 5 | \(8.3\times 10^{-6}\) | \(4.7\times 10^{-4}\) |
Regulation of expression of SLITs and ROBOs | 6 | \(1.0\times 10^{-5}\) | \(4.7\times 10^{-4}\) |
Formation of a pool of free 40S subunits | 5 | \(1.1\times 10^{-5}\) | \(4.7\times 10^{-4}\) |
Eukaryotic translation termination | 5 | \(1.1\times 10^{-5}\) | \(4.7\times 10^{-4}\) |
Selenocysteine synthesis | 5 | \(1.4\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
Viral mRNA translation | 5 | \(1.5\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
Interleukin-6 signaling | 3 | \(1.5\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
Response of EIF2AK4 (GCN2) to amino acid deficiency | 5 | \(1.6\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
SRP-dependent cotranslational protein targeting to membrane | 5 | \(1.8\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
GTP hydrolysis and joining of the 60S ribosomal subunit | 5 | \(1.9\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
L13a-mediated translational silencing of ceruloplasmin expression | 5 | \(1.9\times 10^{-5}\) | \(4.9\times 10^{-4}\) |
Eukaryotic translation initiation | 5 | \(2.8\times 10^{-5}\) | \(6.4\times 10^{-4}\) |
Cap-dependent translation initiation | 5 | \(2.8\times 10^{-5}\) | \(6.4\times 10^{-4}\) |
Interleukin 6-family signaling | 3 | \(8.0\times 10^{-5}\) | \(1.8\times 10^{-3}\) |