Figure 5 | Scientific Reports

Figure 5

From: Novel Iodine nanoparticles target vascular mimicry in intracerebral triple negative human MDA-MB-231 breast tumors

Figure 5

Fluorescence labeled confocal images (20 ×) of left cerebral hemisphere of athymic nude mice bearing MBD-MD-231 tumors 24 h after iv INP administration. A. Main tumor mass with migrated tumor loci deep into the cerebrum with INP uptake seen as a bright ring. White bar = 100 um. a–e: enlarged fluorescent image of the migrated tumor foci; white bar = 20 um. Tumor cells (td-Tomato, red); INPs (anti-PEG, green); Endothelial stain (antiCD31, violet); Nuclei (Dapi-Blue). Images are of all four colors combined. Intense CD31 stain is seen around blood vessels with associated tumor-cells. Green INP staining does not permit the lower intensity antiCD31 stain to show through.

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