Figure 6

Diagrammatic summary of the relationships between MBD-MB-231 tumor cells, I-SS (vascular mimicry) and INP and CD31 labeling in the inner tumor, the tumor rim and tumor cells that have migrated along blood vessels. A. ISS bounded by tumor cells only; B. ISS bounded by tumor cells partially; C. ISS in the main tumor center, tumor edge and in at the migrated tumor; D. Proposed process of formation and maturation of ISS. INP and CD31 representations are intended to be colocalized.