Table 4 Association of OAC vs OAC + AP with primary outcome according to the CHA2DS2-VASc score subgroup.

From: CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea

 

Crude HR

p

Pint

Cox PH*

p

Pint

IPTWa

p

Pint

All anticoagulated

OAC

Ref

  

Ref

  

Ref

  

OAC + AP

1.61 (1.34–1.93)

 < 0.001

0.04

1.48 (1.22–1.78)

 < 0.001

0.03

1.70 (1.35–2.13)

 < 0.001

0.01

Low score

OAC

Ref

  

Ref

  

Ref

  

OAC + AP

2.41 (1.51–3.82)

0.0002

 

2.56 (1.61–4.08)

 < 0.001

 

3.51 (1.94–6.36)

 < 0.001

 

Intermediate score

OAC

Ref

  

Ref

  

Ref

  

OAC + AP

1.48 (1.11–1.97)

0.01

 

1.53 (1.14–2.05)

0.004

 

1.57 (1.13–2.19)

0.01

 

High score

OAC

1(ref)

  

1(ref)

  

1(ref)

  

OAC + AP

1.19 (0.91–1.57)

0.21

 

1.24 (0.94–1.64)

0.13

 

1.28 (0.93–1.75)

0.13

 
  1. *Adjusted variables: age, NIHSS scores, dyslipidemia, smoking, prior anticoagulant use, prior statin use, prior antihypertensive use, prior antidiabetic use, LAD, glucose, SBP, LDL-cholesterol, multiple lesions, reperfusion therapy, stroke mechanism, CHA2DS2-VASc score.
  2. aWeighted Cox proportional hazards model with robust standard errors.
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