Table 4 Age and sex adjusted hazard ratios of outcome risks in the KNOW-CKD cohort compared to the general population using multivariate Cox regression analysis.

From: Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease

CKD stages

Cardiovascular disease

Composite outcome

Unadjusted

Age, sex adjusted

Unadjusted

Age, sex adjusted

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

General population

Reference

 

Reference

 

Reference

 

Reference

 

All stages

4.60 (3.91, 5.42)

 < 0.001

2.35 (1.99, 2.76)

 < 0.001

3.54 (3.09, 4.05)

 < 0.001

1.67 (1.46, 1.91)

 < 0.001

Stage G1

1.39 (0.68, 2.85)

0.363

1.77 (0.87, 3.62)

0.118

0.95 (0.50, 1.79)

0.866

1.19 (0.63, 2.26)

0.584

Stage G2

4.41 (3.03, 6.41)

 < 0.001

2.87 (1.98, 4.18)

 < 0.001

2.88 (2.05, 4.05)

 < 0.001

1.77 (1.26, 2.48)

0.001

Stage G3a

4.63 (3.11, 6.88)

 < 0.001

2.01 (1.35, 2.99)

 < 0.001

3.31 (2.35, 4.67)

 < 0.001

1.33 (0.95, 1.87)

0.103

Stage G3b

6.23 (4.62, 8.41)

 < 0.001

2.62 (1.94, 3.54)

 < 0.001

4.10 (3.13, 5.37)

 < 0.001

1.61 (1.23, 2.11)

 < 0.001

Stage G4

6.26 (4.57, 8.58)

 < 0.001

2.44 (1.78, 3.35)

 < 0.001

5.60 (4.38, 7.15)

 < 0.001

2.03 (1.59, 2.59)

 < 0.001

Stage G5

4.66 (2.39, 9.09)

 < 0.001

1.91 (0.98, 3.75)

0.059

5.37 (3.41, 8.48)

 < 0.001

2.12 (1.35, 3.34)

0.001

  1. CI confidential interval, CKD chronic kidney disease, HR hazard ratio, UPCR urine protein-to-creatinine ratio.
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