Table 5 Optical coherence tomography and optical coherence tomography angiography parameters of APOE-ε4 carriers and non-carriers.

From: Changes in retinal microvasculature and retinal layer thickness in association with apolipoprotein E genotype in Alzheimer’s disease

 

APOE-ε4 + 

APOE-ε4-

p-value

n

10

18

 

Age, mean ± SD, years

71.1 ± 7.1

73.2 ± 6.5

0.27

Sex (M/F), (n/n)

5/5

13/5

0.41

Retinal microvasculature, mean ± SD

FAZ area (mm2)-SCP

0.32 ± 0.09

0.31 ± 0.10

0.65

FAZ area (mm2)-DCP

1.04 ± 0.24

0.91 ± 0.26

0.21

VD (%)—SCP

14.4 ± 3.8

14.4 ± 3.5

0.83

VD (%)—DCP

24.3 ± 1.8

26.0 ± 2.0

0.03*

Retinal layer thickness, mean ± SD, μm

Total retina

315.8 ± 14.2

316.2 ± 13.8

0.80

RNFL

21.0 ± 3.3

19.8 ± 1.8

0.45

GCL

39.7 ± 4.7

39.7 ± 3.3

0.60

IPL

35.6 ± 1.7

34.6 ± 1.9

0.15

INL

37.9 ± 3.5

36.6 ± 4.2

0.36

OPL

35.2 ± 4.9

32.2 ± 3.1

0.17

ONL

64.7 ± 9.1

69.3 ± 9.5

0.23

RPE

14.7 ± 1.7

15.7 ± 1.4

0.07

  1. APOE = apolipoprotein E, M = male, F = female, FAZ = foveal avascular zone, SCP = superficial capillary plexus, DCP = deep capillary plexus, VD = vessel density, RNFL = retinal nerve fiber layer, GCL = ganglion cell layer, IPL = inner plexiform layer, INL = inner nuclear layer, OPL = outer plexiform layer, ONL = outer nuclear layer, RPE = retinal pigment epithelium, SD = standard deviation.
  2. *p < 0.05.
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