Figure 2

Survival analyses of Molecular-Based Score (MBS) on overall survival (OS) of myelodysplastic syndrome. (A) Kaplan–Meier curves for the three MBS risk categories. (B) MBS was built based on gene expression of ACLY, ANPEP, PANK1, PKM and SLC25A5. MBS efficiently identify three risk groups. (C) Significance (χ2-statistic) of each covariate for prediction of OS in the multivariate model, in which higher values represents increased predictive capacity; df: degrees of freedom. (D) Forest plot for multivariable analysis identified adverse risk-MBS and age as independent predictors of OS. Hazard ratios (HR) > 1 indicates that increasing values for continuous variable or the first factor for categorical variables has the poorer outcome. HR and their respective 95% confidence interval (95%CI) are indicated with black square and a line, respectively. IPSS-R non-low patients included intermediate, high and very-high patients.