Figure 10 | Scientific Reports

Figure 10

From: Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes

Figure 10

Schematic illustration for the effects of ZnONPs and CurNPs on pathways-related T2DM. HFD/STZ induced hyperglycemia, dyslipidemia, cellular stress, insulin resistance, causing the inhibition of PI3K/AKT and activation of p38-MAPK. ZnONPs and CurNPs administration displayed protective mechanisms at cellular and molecular levels. Both nanoparticles could protect tissues from diabetic complications via upregulation of PI3K/AKT pathway, down-regulation of p38-MAPK pathways, and attenuation of oxidative and inflammatory pathways. (↑): Up-regulated targets; (↓) Down-regulated targets.

Back to article page