Figure 3 | Scientific Reports

Figure 3

From: Point mutations in Candida glabrata 3-hydroxy-3-methylglutaryl-coenzyme A reductase (CgHMGR) decrease enzymatic activity and substrate/inhibitor affinity

Figure 3

Structural modeling of the conformational differences between wild-type and mutant HMGR proteins of Candida glabrata (CgHMGR), in flat ribbon representation. (a) Wild-type CgHMGR, (b) mutant CgHMGRE680Q, (c) mutant CgHMGRE711Q, (d) mutant CgHMGRD805A, (e) mutant CgHMGRM807R, and (f) mutant CgHMGRE680Q-M807R. The α monomer is illustrated in pink, the β monomer in cyan, and the mutation in stick representation (red). Made using Discovery Studio software.

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