Table 3 The proteins of the backbone involved in the KEGG pathways.
From: Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information
Pathway | Description | # | Proteins involved in the KEGG pathway |
|---|---|---|---|
hsa04659 | Th17 cell differentiation | 10 | CD4, LCK, MAPK14, NFKBIA, RELA, STAT3, TGFB1, TGFBR1, TGFBR2, ZAP70 (blue) |
hsa04940 | Type I diabetes mellitus | 1 | TNF |
hsa04658 | Th1 and Th2 cell differentiation | 6 | CD4, LCK, MAPK14, NFKBIA, RELA, ZAP70 (green) |
hsa04064 | NF-kappa B signaling pathway | 9 | BIRC2, LCK, NFKBIA, RELA, SYK, TNF, TRAF 2, UBE2I, ZAP70 (yellow) |
hsa04210 | Apoptosis | 8 | BIRC2, CASP3, CASP8, NFKBIA, PIK3R1, RELA, TNF, TRAF2 (pink) |
hsa04668 | TNF signaling pathway | 9 | BIRC2, CASP3, CASP8, MAPK14, NFKBIA, PIK3R1, RELA, TNF, TRAF2 (orange) |
hsa04060 | Cytokine-cytokine receptor interaction | 7 | CCR5, EGFR, IL18, TGFB1, TGFBR1, TGFBR2, TNF |
hsa04660 | T cell receptor signaling pathway | 11 | CBLB, CD4, CTLA4, FYN, LCK, MAPK14, NFKBIA, PIK3R1, RELA, TNF, ZAP70 |
hsa04620 | Toll-like receptor signaling pathway | 6 | CASP8, MAPK14, NFKBIA, PIK3R1, RELA, TNF |
hsa04010 | MAPK signaling pathway | 11 | ARRB1, CASP3, EGFR, IGF1R, MAPK14, RELA, TGFB1, TGFBR1, TGFBR2, TNF, TRAF2 |
hsa04910 | Insulin signaling pathway | 4 | CBL, CBLB, PIK3R1, SHC1 |
hsa04630 | Jak-STAT signaling pathway | 5 | CREBBP, EGFR, PIK3R1, PTPN11, STAT3 |
hsa04151 | PI3K-Akt signaling pathway | 5 | EGFR, IGF1R, PIK3R1, RELA, SYK |
