Table 4 The T1D-related miRNAs targeting backbone proteins.

From: Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information

Proteins

#

miRNAs

AGT

0

 

AGTR1

2

miR-155-5p, miR-34a-5p

APP

11

let-7g-3p, miR-103a-3p, miR-148a-3p, miR-155-5p, miR-181a-3p, miR-181a-5p, miR-20a-5p, miR-210-3p, miR-21-3p, miR-23b-3p, miR-34a-3p

ARRB1

4

miR-146a-5p, miR-155-5p, miR-20a-5p, miR-34a-5p

BIRC2

6

let-7g-5p, miR-149-5p, miR-20a-5p, miR-210-3p, miR-23b-3p, miR-34a-5p

CASP1

2

miR-21-3p, miR-34a-5p

CASP3

10

let-7g-5p, miR-100-5p, miR-1275, miR-155-5p, miR-20a-3p, miR-21-3p, miR-23a-3p, miR-23b-3p, miR-34a-5p, miR-375

CASP8

5

miR-146a-5p, miR-155-5p, miR-20a-5p, miR-21-5p, miR-34a-5p

CAV1

7

miR-103a-3p, miR-155-5p, miR-192-5p, miR-20a-5p, miR-210-3p, miR-23b-3p, miR-24-3p

CBL

8

let-7g-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-155-5p, miR-23a-3p, miR-23b-3p, miR-24-3p

CBLB

2

miR-146a-5p, miR-21-3p

CCR5

3

let-7g-5p, miR-103a-3p, miR-21-3p

CD4

3

miR-100-5p, miR-181a-5p, miR-23b-3p

CDC5L

3

miR-181a-5p, miR-20a-5p, miR-34a-5p

CREBBP

4

miR-100-5p, miR-103a-3p, miR-20a-3p, miR-24-3p

CTLA4

1

miR-155-5p

CTNNB1

14

miR-103a-3p, miR-155-5p, miR-181a-5p, miR-200a-3p, miR-20a-3p, miR-210-3p, miR-21-3p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-24-3p, miR-34a-3p, miR-34a-5p, miR-375

EGFR

12

let-7g-3p, miR-103a-3p, miR-146a-5p, miR-155-5p, miR-181a-5p, miR-200a-3p, miR-21-3p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-24-3p, miR-34a-5p

ESR1

7

miR-100-5p, mir-181a, miR-192-5p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-24-3p

FYN

8

let-7g-3p, miR-155-5p, miR-20a-5p, miR-210-3p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-34a-5p

IGF1R

14

let-7g-3p, let-7g-5p, miR-100-5p, miR-103a-3p, miR-1275, miR-148a-3p, miR-181a-5p, miR-192-5p, miR-20a-5p, miR-21-5p, miR-342-3p, miR-34a-3p, miR-34a-5p, miR-375

IL16

1

miR-155-5p

IL18

5

miR-103a-3p, miR-146a-5p, miR-155-5p, miR-210-3p, miR-24-3p

LCK

1

miR-210-3p

MAPK14

5

miR-103a-3p, miR-149-5p, miR-155-5p, miR-200a-3p, miR-24-3p

NFKBIA

8

leg-7g-3p, miR-155-5p, miR-200a-3p, miR-20a-5p, miR-21-3p, miR-23b-3p, miR-24-3p, miR-34a-5p

NOS2

1

miR-146a-5p

PIK3R1

8

miR-103a-3p, miR-155-5p, miR-181a-5p, miR-20a-5p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-487a-3p

PRKCD

3

miR-155-5p, miR-181a-5p, miR-20a-5p

PTPN11

7

miR-100-5p, miR-146a-5p, miR-181a-5p, miR-210-3p, miR-21-3p, miR-23a-3p, miR-34a-5p

RELA

3

miR-155-5p, miR-24-3p, miR-34a-4p

SHC1

2

miR-155-5p, miR-200a-3p

SNCA

6

miR-103a-3p, miR-155-5p, miR-20a-5p, miR-23a-3p, miR-23b-3p, miR-34a-5p

SRC

4

miR-146a-5p, miR-155-5p, miR-23b-3p, miR-34a-5p

STAT3

14

let-7g-5p, miR-148a-3p, miR-155-5p, miR-181a-5p, miR-200a-3p, miR-20a-3p, miR-20a-5p, miR-21-3p, miR-21-5p, miR-210-3p, miR-23a-3p, miR-23b-3p, miR-34a-5p, miR-375

SYK

1

miR-210-3p

TGFB1

6

miR-103a-3p, miR-146a-5p, miR-21-5p, miR-23b-3p, miR-24-3p, miR-34a-5p

TGFBR1

9

let-7g-3p, let-7g-5p, miR-103a-3p, miR-148a-3p, miR-181a-5p, miR-20a-5p, miR-210-3p, miR-21-5p, miR-34a-3p

TGFBR2

12

let-7g-3p, let-7g-5p, miR-103a-3p, miR-148a-3p, miR-155-5p, miR-181a-5p, miR-20a-5p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-24-3p, miR-34a-5p

TNF

3

miR-155-5p, miR-24-3p, miR-34a-5p

TOR1A

2

let-7g-5p, miR-34a-5p

TRAF2

1

miR-34a-5p

UBB

6

miR-100-5p, miR-192-5p, miR-20a-5p, miR-23a-3p, miR-23b-3p, miR-34a-3p

UBC

5

miR-155-5p, miR-20a-5p, miR-24-3p, miR-326, miR-34a-5p

UBE2I

3

let-7g-5p, miR-181a-5p, miR-34a-5p

ZAP70

1

miR-34a-5p