Table 3 The univariable and multivariable Cox proportional hazards models for risk factors of ATE.

From: Accelerated fibrin clot degradation is associated with arterial thromboembolism in patients following venous thrombosis: a cohort study

Variable

HR per

Univariable

Multivariable

HR (95% CI)

P

HR (95% CI)

P

Age

1 year

1.05 (1.01–1.1)

0.02

1.05 (1.005–1.1)

0.03

Male sex

No/Yes

0.81 (0.34–1.91)

0.62

0.68 (0.28–1.65)

0.4

Duration of anticoagulation

1 month

1.07 (0.96–1.19)

0.23

  

Unprovoked VTE

No/Yes

1.09 (0.46–2.56)

0.85

  

Smoking

No/Yes

1.15 (0.47–2.76)

0.76

  

Diabetes

No/Yes

3.96 (1.17–13.45)

0.03

3.75 (1.08–12.98)

0.04

Hypercholesterolemia

No/Yes

1.06 (0.36–3.15)

0.92

  

CRP

1 mg/L

0.86 (0.58–1.27)

0.45

  

Fibrinogen

1 g/L

1.3 (0.84–2.03)

0.24

1.46 (0.92–2.3)

0.1

D-dimer

100 mg/dL

0.99 (0.64–1.54)

0.98

  

ETP

0.001 nM x min

0.58 (0.1–3.21)

0.53

  

Ks

1 × 10–9 cm2

0.69 (0.45–1.04)

0.08

  

Lag phase

1 s

0.98 (0.9–1.07)

0.65

  

ΔAbs

0.01

1.06 (0.99–1.13)

0.11

  

D-Dmax

1 mg/L

1.45 (0.66–3.17)

0.35

  

D-Drate

0.001 mg/L/min

1.07 (1.01–1.13)

0.01

1.08 (1.02–1.14)

0.01

CLT

1 min

0.99 (0.97–1.02)

0.63

  

Recurrent VTE

No/Yes

0.81 (0.3–2.2)

0.68

0.04 (0.35–3.09)

0.94

  1. HR hazard ratio, CI confidence interval, CRP C-reactive protein, ETP endogenous thrombin potential, for other abbreviations see Tables 1 and Table 2.
  2. In terms of ATE two patients excluded from the previous analysis were included in the current follow-up study.
  3. Twenty-one patients with ATE and 289 patients without ATE were included in the Cox proportional hazards models.
  4. Age, gender, diabetes, fibrinogen, D-D rate and recurrent VTE were included in the multivariable model.
  5. C-statistic = 0.73.
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