Figure 3 | Scientific Reports

Figure 3

From: Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase

Figure 3

(A) Inhibitors of c-Abl Kinase block Riluzole-induced apoptosis. (A) Cytotoxicity was measured using MTT assay in LM7 cells in the presence of 100 μM Riluzole, or PPY A or GNF-5 or Riluzole + PPY A or Riluzole + GNF-5, p value < 0.0001***. (B) Subcellular localization of YAP in the presence of Riluzole (100 μM) or Riluzole + PPY A (20 nM) or Riluzole + GNF-5 (220 nM), p value < 0.05**. (C) Intracellular ROS was measured in LM7 cells treated with Riluzole or H2O2 as a positive control. These experiments were repeated three times with triplicate samples, p value < 0.05**.

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