Figure 2 | Scientific Reports

Figure 2

From: Insights into phenotypic differences between humans and mice with p.T721M and other C-terminal variants of the SLC26A4 gene

Figure 2

Auditory phenotypes. (A) The ABR waveforms in clicks did not differ significantly among heterozygous Slc26a4+/T721M, homozygous Slc26a4T721M/T721M, compound heterozygous Slc26a4919-2A>G/T721M, and wild-type Slc26a4+/+ mice. The ABR waveforms of Slc26a4919-2A>G/919-2A>G mice with profound hearing loss were also determined for comparison. (B) Heterozygous, homozygous, and compound heterozygous mice showed normal hearing thresholds across different frequencies, similar to those in wild-type Slc26a4+/+ mice. There were no significant differences among these four groups of mice at 12, 28, and 44 weeks.

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