Table 3 Univariate and multivariate analysis of baseline demographic, clinical and nodule characteristics associated with malignant transformation of nodules to hepatocellular carcinoma.
From: Liver disease severity predicts carcinogenesis of dysplastic liver nodules in cirrhosis
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Hazard ratio* | 95% CI | P | Hazard Ratio** | 95% CI** | P | |
Gender: male | 1.05 | 0.46–2.39 | 0.91 | 3.71 | 0.34–40.93 | 0.28 |
Age (years) | 0.99 | 0.96–1.02 | 0.39 | 1.02 | 0.94–1.11 | 0.66 |
Age > 60 years | 1.22 | 0.51–2.92 | 0.66 | |||
Weight (kg) | 1.00 | 0.97–1.02 | 0.68 | |||
BMI (kg/m2) | 1.03 | 0.97–1.09 | 0.38 | |||
Diabetes | 1.83 | 0.78–4.27 | 0.17 | |||
Past HCC | 0.62 | 0.14–2.66 | 0.52 | |||
Current HCC | 1.42 | 0.48–4.19 | 0.53 | |||
Nodule size (mm) | 1.01 | 0.95–1.08 | 0.77 | |||
AFP (ng/ml) | 1.00 | 1.00–1.00 | 0.94 | |||
Child–Pugh score (per unit increase) | 1.83 | 1.45–2.30 | < 0.001 | |||
Child Pugh status | ||||||
A (reference) | – | |||||
B | 4.63 | 1.62–13.24 | 0.004 | 10.1 | 1.22–84 | 0.03 |
C | 16.2 | 4.66–56 | < 0.001 | 32.6 | 2.27–467 | 0.01 |
MELD (per unit increase) | 1.14 | 1.06–1.24 | < 0.001 | |||
ALBI grade | ||||||
1 (reference) | – | |||||
2 | 1.26 | 0.34–4.65 | 0.73 | |||
3 | 13.5 | 3.63–50 | < 0.001 | |||
