Figure 3 | Scientific Reports

Figure 3

From: Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth

Figure 3

Preterm birth alters the cell subtype proportion of the kidney. A cell subtype proportion analysis on RNA-seq data showed kidneys from the preterm group had a decreased proportion of nephron progenitor 1 cells (NP1) and an increased proportion of NP2 cells (NP). The cell proportion of endothelial cells and podocytes was also lower in the preterm group. Identified cell subtype clusters in the scRNA-seq data (b). The nephron progenitor subpopulation marker genes Cited1 and Sfrp1 were used to classified the NP subpopulations with Cited1 marking the nephron progenitor 1 cluster (NP1) (c) and Sfrp2 marking the more differentiated nephron progenitor 2 cluster (NP2) (d). *Abbreviations in part b: NP1–3, nephron progenitor cells 1–3; UB_T, ureteric bud tip cells; Str_1–3, stromal cells 1–3; Pod, podocytes; PT1–2, proximal tubule 1–2; LOH, Loop of Henle; DT, distal tubule; CD, collecting duct; End, endothelium.

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