Figure 3 | Scientific Reports

Figure 3

From: Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions

Figure 3

We generated finite element models for each subject individually by segmenting axial MRI through the lateral ventricle. (a) We identified the boundaries of gray matter, white matter, lateral ventricles, and cerebral spinal fluid surrounding the cortex. (b) The model was kinematically constrained along the outer boundary, and we applied a pressure normal to the ventricular wall (b1) and normal to the outer gray matter surface (b2). (c) Accompanying FLAIR images superposed with a mask of white matter hyperintensities show the localization of early leukoaraiosis in the ventricular horns (c3). We simulated peak loading during the hemodynamic pressure cycle in order to obtain the strain field (d4) and ependymal cell stretch along the ventricular wall (d5).

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