Table 1 Karyotype of MBU-7, MBU-8 and U-937.

From: Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18

Cell line

Karyotype

MBU-7

56<3n>,XX,− Y, − 1,der(1)t(1;5)(p22;q31.1),− 2,add(2)(q37),add(3)(q12), der(3)t(1;3)(q21;q26),− 4,− 5,der(5)t(1;5)(p22;q23.3),− 6,add(6)(p25),− 8,− 9,− 10, der(10)t(10;11)(p12;q14),− 11,del(11)(q22),− 12,add(12)(p12),− 13, der(13)t(1;13)(p32;p11.2),− 14,− 15,− 16,add(16)(p11.1),− 17,− 18,− 19,− 22, del(22)(q13.2q13.3), + 6mar

MBU-8

58<3n>,XX,− Y, − 1,der(1)t(1;5)(p22;q31.1),− 2,add(2)(q37),add(3)(q12), der(3)t(1;3)(q21;q26),− 4,− 5,der(5)t(1;5)(p22;q23.3),− 6,add(6)(p25), del(7)(q31.1q36.3),i(8)(p10),− 9,− 10,der(10)t(10;11)(p12;q14),− 11, del(11)(q22),− 12,add(12)(p12),− 13,der(13)t(1;13)(p22.3;p11.2),− 14,− 15,− 16, add(16)(p11.1),− 17,− 19,− 22,del(22)(q13.2q13.3), + 6mar

U-937 (source: DSMZ)

63(58–69), XXY, t(1;12)(q21;p13),− 2,− 4,der(5)t(1;5)(p22;q35), − 6, + 7, − 9,add(9)(p22),t(10;11)(p14;q23),i(11q),i(12p),add(16)(q22),add(19)(q13), − 20,− 21, + 3mar

U-937 (source: MacKinnon et al.31)

62, XX, − Y, del(1)(q12), + der(1)t(1;5)(p22;q31.1),del(2)(p11.2), + der(2)dup(2)(q24.1q33.1)del(2)(q33.1),del(3)(q13.33q24),  + psu dic(3;1)(q25.1;p11.1),der(5)t(1;5)(p22;q23.3), + der(5)t(5;13)(q11.2;q14.11)del(5)(q11.2q11.2), + der(6)t(2;6)(p13.2;p22.1, + 7, + dup(7)(p15.3p15.1), + 8,der(10)t(10;11)(p12.31;q14.2)t(10;10)(q23.33q25.2),der(11)t(10;11)(p12.31;q14.2), + der(11)(16pter- > 16p11.2::11p11.12- > 11q12::11q24.12- > 11q24.2::20q11.21- > 20q11.21::20p12.3 > 20pter), + 12,  + 15,der(16)t(4;16)(p13;p12.2)del(4)(p14p14)del(4)(p15.1p15.1)del(4)(p15.31p16.1), + 18, + 19,der(20)(20pter- > 20p12.2::15q14- > 15q25.3::20p11.22- > 20q11.21::20p11.21- > 20p11.21:), + 21, + 22 [21]/63,idem, + der(6)del(6)(p21.31)amp(6)(p21.31)dup(6)(p21.31p12.2), del(7)(q22.1q34)[37]/60,idem,der(7)t(6;7)(q27;q21.12), − 12, − 22[13]

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