Figure 4

TMB estimation results for the 10,000 simulated sequencing panels in different datasets. (A) The R-squared of the simulated sequencing panels of the hypermutation-included dataset (blue) and the non-hypermutation dataset (red). The X axis is the size of each simulated panel, and the Y axis is the R-squared value of each panel. (B) The average angular distance of the simulated sequencing panels of the hypermutation-included dataset (blue) and the non-hypermutation dataset (red). The X axis is the size for each simulated panel, and the Y axis is the average angular distance estimated for each simulated panel. (C) The correlation between TMB and average angular distance. The X axis is the WES-based TMB of the patient and the Y axis is the average angular distance of the 10,000 simulated panels. Patients with TMB > 100 are not shown.