Figure 5
From: Optimizing the evaluation of gene-targeted panels for tumor mutational burden estimation
The average angular distance of the simulated sequencing panels in the hypermutation-included dataset using total point mutations (blue) and nonsynonymous mutations (red). The X axis is the size for each simulated panel, and the Y axis is the average angular distance estimated by the simulated panels. The estimation bias is higher when using nonsynonymous mutations as opposed to using total point mutations for the same panels.
