Figure 2 | Scientific Reports

Figure 2

From: The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network

Figure 2

Association between the biologically informed hippocampal polygenic risk score for the insulin receptor gene network (hePRS-IR) and mental component score of the SF-36 (MCS) in individuals with no, non-melancholic or melancholic depressive symptoms. Confidence intervals and P-values were based on the bootstrap style method of 10,000 repetitions. (a) BDI < 10. (b) Non-melancholic depressive symptoms. (c) Melancholic depressive symptoms. Model adjusted for age, sex and population stratification, smoking, alcohol usage, socioeconomic class, body mass index, leisure-time physical activity and comorbidities. MCS mental component score of SF-36, BDI Beck Depression Inventory, hePRS-IR biologically informed hippocampal polygenic risk score for insulin receptor, SD standard deviation.

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