Figure 1
From: Uncovering early events in primary Epstein-Barr virus infection using a rabbit model
Macroscopic visualization of rabbit spleens. (A) Spleen of PBS and (B) CsA from non-infected control animals and (C) infected immunocompetent group. (D–F) EBER-ISH for the detection of EBV showed positive signals only in sections from infected animals, but not in non-infected controls. (G–I) In contrast to healthy immunocompetent animals, the spleens from infected and immunosuppressed animals were greatly enlarged and visibly abnormal. EBER-ISH indicated widespread infection in the spleen of all three immunosuppressed groups, irrespective of when immunosuppression was started, (J) EBV > CsA, (K) EBV + CsA or (L) CsA > EBV. (M) Comparison of viral load by qPCR indicated that the spleen had the highest load, compared to PBMCs and plasma.
