Figure 2 | Scientific Reports

Figure 2

From: Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs

Figure 2

Effects of luCldn-18 deficiency on pulmonary histological findings after infection with C. deneoformans. (a) Lung sections of uninfected luCldn-18+/+ (n = 3) and luCldn-18−/− mice (n = 3) were stained with H-E and observed under a light microscope at ×40 (upper panels) and ×200 (under panels). Red arrows show alveolar macrophages. (b) luCldn-18+/+ and luCldn-18−/− mice were infected intratracheally with C. deneoformans. Sections of the lungs on day 14 post-infection were stained with H-E or PAS and observed under a light microscope. Original magnifications: upper panels, the upper lobe of the left lungs; middle panels, ×40; lower panels, ×200. Representative pictures are shown. Black arrows show granulomas. (c) The proportions of granulomatous areas were calculated. Each column represents the mean ± SD of 3 mice. *, p < 0.05.

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