Figure 2
From: Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data
Age-associated transcriptomic changes of the matrisome. (a) A plot indicating the 32 transcripts with the largest change in expression relative to age. The transcript with the smallest FDR-adjusted p-value per tissue is noted along with all other instances of that transcripts having a β estimate ≥ 0.15 in other tissues. Tissues with no significant findings (FDR-adjusted p > 0.05) were not included. (b) Representative images of the transverse colon with varying levels of multi-tissue ADIPOQ expression at two different powers. The left sample, GTEX-14C5O, had low levels of ADIPOQ and is notable for a thin submucosa (two-headed arrow) with few adipocytes. The right sample, GTEX-1KXAM, had high levels of ADIPOQ, with a notable submucosal area containing large numbers of adipocytes. The bars are 1 mm and 200 µm for the low and high power views respectively. (c) A scatterplot representing the percent of adipose tissue in the submucosa of the transverse colon for the top 6 and bottom 8 individuals ordered on body wide ADIPOQ expression. The datapoints (n = 2 to 6, median of 6, per individual) of multiple measured areas per sample are colored to represent the top (blue) or bottom (yellow) multi-tissue ADIPOQ expressors. Bars indicate the median level of submucosal adipocytes for each individual.
