Figure 3
From: Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data
Sex based differences in the matrisome transcriptome. (a) A plot of sex DE genes. The transcript with the smallest p-value per tissue is noted along with all instances of that transcript having a significant β estimate in other tissues. Tissues with no significant findings were not included. (b) The sex-related genes that are DE in ADPSBQ and ADPVSC. Notably, ADPSBQ has 81 DE genes while ADPVSC has only 10. (c) The sex-related genes that are DE in skin not sun exposed (SKINNS) and skin sun exposed (SKINS). The size of the dot indicates the β estimate. The tissues are mostly congruent, having 17 shared genes with the same expression directionality. (d) A barplot comparing the Z score for the ADPSBQ ADP-Fib.1 gene cluster between males and females for both ADPSBQ and ADPVSC tissues. In ADPSBQ, which has more DE sex genes, cluster ADP-Fib.1 associates with the male sex. This cluster shares 11 genes with the DE gene list in (b). In ADPVSC, there is no sex difference. *=1.96e−05 (e) Adipose samples from two individuals showing differing levels of fibrosis. The top samples are from GTEX-IGN73 and the bottom samples are from GTEX-1K2DA. The left samples are ADPSBQ and the right samples are ADPVSC. The bar is 200 um. (f) The median percent adipose tissue from ADPSBQ (n = 34; 16F/18M) and ADPVSC n = 34; 16F/18M) samples, with the ADP-Fib.1 Z-score on the X axis. This data shows that the gene transcripts in the ADP-Fib.1 cluster positively correlate with adiposity and negatively correlate with fibrosis in ADPSBQ tissue.
