Table 1 Top five enriched Gene ontology biological processes for each differentially expressed protein (DEP) classes in the hippocampus. For the five hippocampal (HC)-DEP classes, top five enriched Gene ontology biological processes are summarized.
From: Proteins related to ictogenesis and seizure clustering in chronic epilepsy
Term | Fold enrichment | P value | FDR |
|---|---|---|---|
HC-class 1: inversely cluster-related DEPs | |||
Dicarboxylic acid metabolic process |  < 0.001 |  < 0.001** |  < 0.001 |
Organic acid metabolic process |  < 0.001 |  < 0.001** |  < 0.001 |
Carboxylic acid metabolic process | 0.001 |  < 0.001** | 0.002 |
Oxoacid metabolic process | 0.001 |  < 0.001** | 0.003 |
Oxidation–reduction process | 0.004 |  < 0.001** | 0.014 |
HC-class 2: cluster-onset downregulated DEPs | |||
Energy derivation by oxidation of organic compounds | 0.892 | 0.001** | 1.794 |
Generation of precursor metabolites and energy | 0.991 | 0.004** | 7.461 |
Regulation of G-protein coupled receptor protein signaling pathway | 0.969 | 0.005** | 8.168 |
Central nervous system neuron axonogenesis | 0.953 | 0.006** | 9.464 |
Regulation of cation transmembrane transport | 0.943 | 0.007** | 11.045 |
HC-class 3: cluster-onset upregulated DEPs | |||
Regulation of cell morphogenesis | 0.717 | 0.001** | 1.565 |
Cellular protein complex assembly | 0.894 | 0.003** | 5.447 |
Regulation of filopodium assembly | 0.839 | 0.004** | 6.616 |
Filopodium assembly | 0.839 | 0.004** | 6.616 |
Neuron projection morphogenesis | 0.827 | 0.005** | 8.388 |
HC-class 4: positively cluster-related DEPs | |||
Organonitrogen compound biosynthetic process |  < 0.001 |  < 0.001** |  < 0.001 |
Translation | 0.004 |  < 0.001** | 0.006 |
Peptide biosynthetic process | 0.003 |  < 0.001** | 0.008 |
Amide biosynthetic process | 0.008 |  < 0.001** | 0.025 |
Peptide metabolic process | 0.015 |  < 0.001** | 0.062 |
HC-class 5 | |||
Establishment of protein localization to organelle | 0.707 | 0.001** | 1.286 |
Wnt signaling pathway | 0.605 | 0.001** | 1.942 |
Cell–cell signaling by wnt | 0.465 | 0.001** | 1.964 |
Cell surface receptor signaling pathway involved in cell–cell signaling | 0.634 | 0.003** | 4.157 |
Apoptotic process | 0.559 | 0.003** | 4.232 |
