Table 3 Seizure-related function of the key differentially expressed proteins in classes 2 and 3.
From: Proteins related to ictogenesis and seizure clustering in chronic epilepsy
Protein | Abbreviation | Seizure-related function |
|---|---|---|
HC-class 2: cluster-onset downregulated DEPs | ||
Protein kinase C alpha | Prkca | Synaptic plasticity by trafficking of N-Methyl-D-Aspartate receptors |
Ezrin | Ezr | Cytoskeleton-membrane interference, cell growth, migration, and differentiation |
Calcium-binding protein B | S100b | Promote cell survival, differentiation, neurite outgrowth, anti-apoptosis of neurons, stimulate Ca2+ uptake in neurons and astrocytes |
Solute carrier family 8 member A1 | Slc8a1 | Sodium-calcium exchanger that removes calcium from cells |
Alpha-synuclein | Snca | Production of alpha-synuclein |
HC-class 3: cluster-onset upregulated DEPs | ||
Dynamin-3 | Dnm3 | Synaptic vesicle assembly, dendritic spine morphogenesis and remodeling |
Calcium-dependent secretion activator | Cadps | Synaptic vesicle assembly, Ca2+ dependent neurotransmitter and neurotrophin release in synapse |
Synaptotagmin-2 | Syt2 | Synaptic vesicle assembly, Ca2+ dependent exocytosis of synaptic vesicles, neurotransmitter release |
Synaptotagmin-6 | Syt6 | Ca2+ dependent exocytosis of synaptic vesicles, neurotransmitter release |
Fascin-1 | Fscn1 | Dynamic projections of neuronal dendrites, regulate processes of axonal motility and synaptic function |
