Figure 5 | Scientific Reports

Figure 5

From: Metacyclogenesis defects and gene expression hallmarks of histone deacetylase 4-deficient Trypanosoma cruzi cells

Figure 5

TcHDAC4 histone post-translational modifications targets. (A) Number of distinct acetylation sites identified for each condition. (B) Numbers of distinct PTMs identified for each condition. (C) Comparison of the global PTM levels in epimastigotes (epi) and metacyclic trypomastigotes (meta) from wild type (WT) and mutant (KO) cells using the average of the peptide intensity (me, monomethylation; me2, dimethylation; me3 trymethylation; Ac, acetylation; Ph, phosphorylation; Hib: 2-hydroxyisobutyrylation; Su: succinylation; Ub: ubiquitination; Cit: citronylation; OH: hydroxylation). (D) Flowchart describing the steps to determine the potential acetylation sites modulated by TcHDAC4 in T. cruzi metacyclic trypomastigotes. (E) Acetylation levels of the putative TcHDAC4 specific target sites. The graph shows the PSM normalized area of the peptide intensity for the peptides containing acetylated threonine 85 in histone H2A (H2AT85Ac), acetylated lysine 10 in histone H4 (HK410Ac) and acetylated threonine 78 in histone H4 (H4T78ac). *indicates p value = 0.0296.

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