Figure 6
From: Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition
ADR-induced NPR3 KO mice exhibited podocyte protective effects similar to OSTN-Tg mice. (a) Light microscopic analysis stained with PAS. Bars, 20 μm. (b) Immunohistochemical study for desmin (magnification, × 400). Bars, 20 μm. (c,d) Electron microscopic analysis with lower magnification (c; magnification, × 2000, Bars, 10 μm), and higher magnification (d; magnification, × 15,000, Bars, 500 nm). (e) Desmin-positive areas were analyzed. (f) Thickness of glomerular basement membrane (GBM) and width of foot process effacements were measured. GBM thickness: PAS periodic acid-Schiff, EM electron microscopy, CT control mice, Tg OSTN-Tg mice. Data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA analysis.
