Figure 7
From: Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition
p38 MAPK phosphorylation in NPR3 KO mice was lower than that of control mice. (a) Glomerular p38 MAPK phosphorylation in four groups at 10 weeks of age. The grouping of gels cropped from the same lines of the same gel. Full-length blots/gels are presented in Supplementary Fig. S13b. (b) Glomerular mRNA expression levels of Ccl2 in four groups at 10 weeks of age. (c–e) Immunofluorescent studies for MCP1 (c; red), nephrin (d; green), and merged images (e) in four groups. (f,g) Immunohistochemical findings of MAC-2 (f), a macrophage marker, and the number of MAC-2-positive cells in glomeruli in four groups (g). Phospho p38, phosphorylated p38 MAPK; CT, control mice; Tg, OSTN-Tg mice. Data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA analysis.
