Figure 2 | Scientific Reports

Figure 2

From: Impact of spaceflight and artificial gravity on sulfur metabolism in mouse liver: sulfur metabolomic and transcriptomic analysis

Figure 2

Downregulation of sulfur compounds in the livers of mice exposed to a spaceflight. (a) An illustration of the reduction and oxidization network of glutathione. Glutathione (GSH), glutathione disulfide (GSSG), and their persulfidated derivatives GS-SH, GS-S2H, GS-S3H, GS-S-SG, GS-S2-SG, and GS-S3-SG. or indicates a significant decrease in A1G or MG mice compared to GC mice. GC, control mice on Earth; A1G, mice under artificial earth gravity in space; MG, mice under microgravity in space. (b) The ratio of the relative amount of GSH to GSSG. Each horizontal bar represents the mean. Dot plots were made using GraphPad Prism 6.07 for Windows, GraphPad Software, San Diego, CA USA, www.graphpad.com. (c) An illustration of the metabolic network of sulfur compounds in mammals. and between compounds indicates metabolic reactions in mammals. or indicates a decrease in A1G or MG mice compared to GC mice. MAT, methionine adenosyltransferase. *P < 0.05. Comparisons of parameters were performed with one-way ANOVA followed by Dunnett’s test for multiple comparisons (n = 6 each).

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