Figure 5 | Scientific Reports

Figure 5

From: TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction

Figure 5

Expression of β-galactosidase and p16 in the glomeruli of patients with kidney diseases. (a) β-galactosidase was detected in glomeruli of patients with kidney disease. (b) p16 is expressed in endothelial, mesangial cells, and extracapillary cells/podocytes in patients with various human kidney diseases. Representative pictures of each pattern are shown. β-gal: β-galactosidase. Col IV: Collagen IV. Cont.: Control (N = 3). MCD: Minimal change disease (N = 3). Lupus III, IV: Systemic lupus nephritis class III or IV (N = 6). Lupus V: Systemic lupus nephritis class V (N = 3). IgA: IgA nephropathy (N = 6). Purp.: Purpura nephritis (N = 4). MPGN: Membranoproliferative glomerulonephritis (N = 3). MN: Membranous nephropathy (N = 3). ANCA: ANCA glomerulonephritis (N = 6). DN: Diabetic nephropathy (N = 6). White column: Endothelial cells. Grey column: Mesangial cells. Black column: Extracapillary cells and podocytes.

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