Table 4 The SNPs associated with the outcomes of unrelated CBT in donor genotype analysis.
SNP | Gene | Chromosome position (bp) | Source | Outcome/ Status | Donor genotype frequency (%) | Test | p-value | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|---|
rs435766 | MICD | Chr6: 29,939,852 | rs2523957 | CMV | AA | AG | GG | Recessive | 0.031 | 4.667 (1.251–17.409) |
Yes | 7 (58.3) | 6 (17.6) | 6 (33.3) | |||||||
No | 5 (41.7) | 28 (82.4) | 12 (66.7) | |||||||
rs380924 | MICD | Chr6: 29,939,885 | rs2523957 | CMV | AA | AG | GG | Recessive | 0.031 | 0.214 (0.057–0.799) |
Yes | 6 (33.3) | 6 (17.6) | 7 (58.3) | |||||||
No | 12 (66.7) | 28 (82.4) | 5 (41.7) | |||||||
rs2523957 | MICD | Chr6: 29,940,260 | rs2523957 | CMV | AA | AG | GG | Recessive | 0.031 | 0.214 (0.057–0.799) |
Yes | 6 (33.3) | 6 (17.6) | 7 (58.3) | |||||||
No | 12 (66.7) | 28 (82.4) | 5 (41.7) | |||||||
rs213210 | RING1 | Chr6: 33,175,824 | rs107822 | GVHD = 3 & 4 | AA | AG | GG | Recessive | 0.028 | 0.217 (0.058–0.817) |
Yes | 6 (42.9) | 6 (17.6) | 1 (6.3) | |||||||
No | 8 (57.1) | 28 (82.4) | 15 (93.8) | |||||||
rs2523675 | HCP5 | Chr6: 31,436,032 | rs2244546 | GVHD = 3 & 4 | AA | AG | GG | Dominant | 0.016 | 5.20 (1.430–18.912) |
Yes | 4 (25.0) | 1 (3.6) | 8 (40.0) | |||||||
No | 12(75.0) | 27 (96.4) | 12 (60.0) | |||||||
