Table 6 The SNPs associated with the outcomes of unrelated CBT in donor-recipient pairs analysis.
SNP | Gene | Chromosome position (bp) | Source | Outcome/status | Genotypes between the Donor-Recipient Pairs (%) | p-value | OR (95% CI.) | |
|---|---|---|---|---|---|---|---|---|
rs9282369 | HLA-DOA | Chr6: 32,978,788: | rs429916 | Survival | Matched | Not matched | 0.005 | 0.181 (0.052–0.628) |
32,978,789 | Yes | 13 (56.5) | 36 (87.8) | |||||
No | 10 (43.5) | 5 (12.2) | ||||||
rs2070120 | HLA-DOB | Chr6: 32,780,914 | rs2071479 | Survival | Matched | Not matched | 0.014 | 7.667 (1.569–37.458) |
Yes | 46 (82.1) | 3 (37.5) | ||||||
No | 10 (17.9) | 5 (62.5) | ||||||
rs17220087 | HLA-DOB | Chr6: 32,781,076 | rs2071479 | Survival | Matched | Not matched | 0.014 | 7.667 (1.569–37.458) |
Yes | 46 (82.1) | 3 (37.5) | ||||||
No | 10 (17.9) | 5 (62.5) | ||||||
rs17213693 | HLA-DOB | Chr6: 32,781,121 | rs2071479 | Survival | Matched | Not matched | 0.014 | 7.667 (1.569–37.458) |
Yes | 46 (82.1) | 3 (37.5) | ||||||
No | 10 (17.9) | 5 (62.5) | ||||||
rs2070120 | HLA-DOB | Chr6: 32,780,914 | rs2071479 | CMV | Matched | Not matched | 0.044 | 0.200 (0.042–0.946) |
Yes | 14 (25.0) | 5 (62.5) | ||||||
No | 42 (75.0) | 3 (37.5) | ||||||
rs17220087 | HLA-DOB | Chr6: 32,781,076 | rs2071479 | CMV | Matched | Not matched | 0.044 | 0.200 (0.042–0.946) |
Yes | 14 (25.0) | 5 (62.5) | ||||||
No | 42 (75.0) | 3 (37.5) | ||||||
rs17213693 | HLA-DOB | Chr6: 32,781,121 | rs2071479 | CMV | Matched | Not matched | 0.044 | 0.200 (0.042–0.946) |
Yes | 14 (25.0) | 5 (62.5) | ||||||
No | 42 (75.0) | 3 (37.5) | ||||||
rs435766 | MICD | Chr6: 29,939,852 | rs2523957 | CMV | Matched | Not matched | 0.009 | 6.800 (1.402–32.972) |
Yes | 17 (40.5) | 2 (9.1) | ||||||
No | 25 (59.5) | 20 (90.9) | ||||||
rs380924 | MICD | Chr6: 29,939,885 | rs2523957 | CMV | Matched | Not matched | 0.014 | 6.212 (1.279–30.159) |
Yes | 17 (39.5) | 2 (9.5) | ||||||
No | 26 (60.5) | 19 (90.5) | ||||||
rs1264813 | MICD | Chr6: 29,939,900 | rs2523957 | CMV | Matched | Not matched | 0.042 | 4.690 (0.959–22.933) |
Yes | 17 (37.0) | 2 (11.1) | ||||||
No | 29 (63.0) | 16 (88.9) | ||||||
rs209130 | TRIM27 | Chr6: 28,867,800 | rs209130 | GVHD = 3 & 4 | Matched | Not matched | 0.043 | 3.625 (0.996–13.194) |
Yes | 10 (71.4) | 4 (28.6) | ||||||
No | 20 (40.8) | 29 (59.2) | ||||||
rs986522 | COL11A2 | Chr6: 33,135,962 | rs986522 | GVHD = 3 & 4 | Matched | Not matched | 0.021 | 0.210 (0.051–0.856) |
Yes | 3 (23.1) | 10 (76.9) | ||||||
No | 30 (58.8) | 21 (41.2) | ||||||
