Figure 3 | Scientific Reports

Figure 3

From: Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression

Figure 3

Representative images showing histological features of nasal tissues in (A) chronic rhinosinusitis mice without allergic rhinitis and (B) chronic rhinosinusitis mice with allergic rhinitis. Increased number of goblet cells, increased mucus production, decreased claudin-1 and e-cadherin staining are found in tissue sections of CRSwoAR and CRSwAR. Control: without rhinosinusitis; CRSwoAR: chronic rhinosinusitis without allergic rhinitis; CRSwAR: chronic rhinosinusitis with allergic rhinitis; EM: erythromycin; Dex: dexamethasone; H&E: hematoxylin and eosin staining; PAS: periodic acid-Schiff staining. Arrow heads mark the eosinophils; arrows mark the representative goblet cells, PAS staining, e-cadherin and claudin-1 staining cells.

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