Table 1 Demographic and baseline characteristics and outcomes of VLBWIs according to different respiratory support approaches (n = 1849).
From: Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
NIH criteria | NRN criteria | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
No BPD (n = 628) | Mild (n = 665) | Moderate (n = 184) | Severe (n = 372) | P | Grade 0 (n = 2052) | Grade 1 (n = 286) | Grade 2 (n = 439) | Grade 3 (n = 112) | P | |
Maternal characteristics | ||||||||||
Maternal age, y | 33.0 ± 3.9 | 32.9 ± 4.1 | 33.4 ± 4.1 | 33.1 ± 3.9 | 0.630 | 33.0 ± 4.0 | 33.4 ± 4.2 | 33.1 ± 3.9 | 32.9 ± 4.3 | 0.507 |
Cesarean section | 479(76) | 483(73) | 130(70) | 300(80) | 0.013 | 963(74) | 132(71) | 245(80) | 52(78) | 0.049 |
Ant. corticosteroids | 525(83) | 552(83) | 153(83) | 318(85) | 0.766 | 1077(83) | 155(83) | 257(84) | 59(89) | 0.557 |
Maternal DM | 61(10) | 57(9) | 25(13) | 27(7) | 0.073 | 118(9) | 25(13) | 20(6) | 6(9) | 0.090 |
Maternal HT | 151(24) | 92(13) | 41(22) | 65(17) | < 0.001 | 243(18) | 42(22) | 52(17) | 12(18) | 0.517 |
Chorioamnionitis * | 222(35) | 259(38) | 81(44) | 176(47) | 0.001 | 481(37) | 82(44) | 144(48) | 30(45) | 0.003 |
Neonatal characteristics | ||||||||||
GA, weeks | 29.5 ± 1.2 | 27.1 ± 1.7 | 27.3 ± 1.9 | 26.5 ± 1.9 | < 0.001 | 28.2 ± 1.9 | 27.3 ± 1.9 | 26.5 ± 1.9 | 26.7 ± 1.8 | < 0.001 |
Birth weight, g | 1233.6 ± 199.9 | 1019.5 ± 226.9 | 997.6 ± 230.9 | 881.8 ± 239.8 | < 0.001 | 1123.6 ± 239.3 | 992.5 ± 234.8 | 888.3 ± 231.3 | 857.8 ± 270.4 | < 0.001 |
SGA | 99(15) | 63(9) | 28(15) | 93(25) | < 0.001 | 162(12) | 30(16) | 70(23) | 21(31) | < 0.001 |
Male | 342(54) | 339(51) | 83(45) | 161(43) | 0.003 | 682(52) | 84(45) | 131(43) | 28(42) | 0.006 |
RDS | 434(69) | 613(92) | 170(92) | 357(96) | < 0.001 | 1048(81) | 172(92) | 288(95) | 66(100) | < 0.001 |
Air leakage | 6(1) | 14(2) | 8(4) | 35(9) | < 0.001 | 20(1) | 8(4) | 25(8) | 10(15) | < 0.001 |
Pulmonary hemorrhage | 3(0.5) | 26(3) | 17(9) | 40(10) | < 0.001 | 41(2) | 23(8) | 37(8) | 21(19) | < 0.001 |
Pulmonary hypertension | 1(0.2) | 20(3) | 10(5) | 64(17) | < 0.001 | 21(1) | 11(6) | 46(15) | 17(25) | < 0.001 |
Postnatal steroid | 25(4) | 198(30) | 71(38) | 244(65) | < 0.001 | 224(17) | 71(38) | 187(61) | 56(84) | < 0.001 |
PDA, treated | 121(19) | 300(45) | 102(55) | 233(62) | < 0.001 | 422(32) | 103(55) | 182(60) | 49(74) | < 0.001 |
Sepsis, culture proven | 50(8) | 128(19) | 46(25) | 147(39) | < 0.001 | 179(13) | 47(25) | 109(36) | 36(54) | < 0.001 |
IVH, grade ≥ 3 | 8(1) | 44(6) | 20(10) | 57(15) | < 0.001 | 52(4) | 20(11) | 44(14) | 13(20) | < 0.001 |
PVL | 34(5) | 42(6) | 27(14) | 50(13) | < 0.001 | 76(6) | 27(14) | 40(13) | 10(15) | < 0.001 |
NEC, stage ≥ 2 | 14(2) | 39(5) | 9(4) | 33(9) | < 0.001 | 53(4) | 9(5) | 24(8) | 9(13) | 0.001 |
