Table 1 RVA diarrhea between 18 and 104 weeks in vaccinated infants following Rotarix dose 2.

From: Oral rotavirus vaccine shedding as a marker of mucosal immunity

 

RVA diarrhea N (%)

No RVA diarrhea N (%)

RR (95% CI)

RVA shedding Ct cut-off < 34

No shedding

38 (26%)

106 (74%)

0.679 (0.415–1.110)

Shedding

14 (39%)

22 (61%)

RVA shedding Ct cut-off < 36

No shedding

31 (24%)

96 (76%)

0.616 (0.392–0.968)

Shedding

21 (40%)

32 (60%)

RVA-IgA

Seropositive

7 (18%)

33 (83%)

0.533 (0.261–1.090)

Seronegative

44 (33%)

90 (73%)

Shedding plus RVA-IgA

No shedding OR seropositive

39 (27%)

108 (73%)

0.597 (0.362–0.984)

Shedding AND seronegative

12 (44%)

15 (56%)

No shedding AND seropositive

5 (16%)

27 (84%)

0.482 (0.208–1.117)

Shedding OR seronegative

46 (32%)

96 (68%)

  1. Seropositive: RVA-IgA ≥ 20 U/mL; seronegative: RVA-IgA < 20 U/mL.
  2. CI confidence interval, Ct cycle threshold, RR relative risk, RVA group A rotavirus.