Table 2 Top 10 gene ontology (GO) terms with statistically significant enrichment (in the order of increasing p-value).
From: Bioinformatic analysis of the gene expression profile in muscle atrophy after spinal cord injury
GO ID | GO term | p value | FDR | Gene symbols | Rank |
|---|---|---|---|---|---|
GO:0,042,493 | Response to drug | 8.56E−16 | 1.51E−12 | |Stat1|Cdk1|Ccnb1|Ddit3|Kcnj11|Lox|Vegfb|Srebf1|Lgals1|Nppc|Emx2|Bdh1|Hadha|Casp3|Tspo|Adipoq|Abcc8|Fabp3|Acsl1|Hadh|Fabp4|Timp4|Txnrd2|Acaca|Oxct1|Acot2|Lpl|Pparg|Mdk|Gnas|Ak4|Aqp7|Gnpat|Ldha|Cd36| | 1 |
GO:0,006,635 | Fatty acid beta-oxidation | 1.02E−13 | 8.97E−11 | |Echs1|Acaa2|Fabp3|Acadvl|Acox2|Adipoq|Hadha|Ech1|Cpt1b|Hadh|Eci1|Hadhb| | 2 |
GO:0,001,666 | Response to hypoxia | 5.44E−11 | 3.20E−08 | |Ddit4|Cat|Adrb2|Ppara|Pak1|Nppc|Mmp14|Kcnma1|Casp3|Sox4|Plod2|Acot2|Pdlim1|Ldha|Egln1|Myocd|Adipoq|Tfrc|Narfl|Cxcl12|Loxl2| | 3 |
GO:0,008,150 | Biological_process | 8.71E−11 | 3.85E−08 | |Gstm5|Ldb3|Tmem106b|Myoc|Ablim1|Smyd2|Impa2|Abca8a|Xpo4|Hccs|Cdkn3|Adam19|Mrpl40|Clmp|Gca|Trim14|Cks2|Ywhah|Baiap2l1|Col5a1|Trim16|Tasp1|Mkks|Cbfb|LOC306766|Xpa|Scn4b|Abhd1|Trim35|Pbx1|Wnt9a|Kif21a|Rpusd4|Adhfe1|Ino80c|Mllt11|Tmem120a|Tmem127|Sorbs1|Opa3|Wnt16|Nrtn|Pcbd1|Kdm8|Gcat|Eya1|Ndufs1|Ndufa8|Col6a1|Clasp1|Cul2|Large|Pex19| | 4 |
GO:0,007,507 | Heart development | 3.69E−10 | 1.31E−07 | |Adam19|Ppp3cb|Ppara|Txnrd2|Col3a1|Kcnj8|Myocd|Alpk3|Pparg|Rxrg|Myl2|Vegfb|Casp3|Cxadr|Sox4|Pkp2|Rps6ka2|Oxct1| | 5 |
GO:0,045,893 | positive regulation of transcription, DNA-dependent | 7.37E−10 | 2.17E−07 | |Stat1|Dnajc2|Tasp1|Patz1|Pparg|Myocd|Mlxipl|Mdk|Ywhah|Klf2|Naa15|Tp63|Kdm8|Ppargc1b|Srebf1|Scx|Trim16|Ppara|Mstn|Sox4|Pcbd1|Eya1|Myf6|Esrra|Lrp5|Mllt11|Trim24|Ddit3| | 6 |
GO:0,009,749 | Response to glucose stimulus | 1.64E−09 | 4.13E−07 | |Nr0b2|Col6a2|Ldha|Glul|Nnat|Mlxipl|Col6a3|Ndufa9|Ctsl1|Irs2|Casp3|Srebf1|Adipoq| | 7 |
GO:0,007,584 | Response to nutrient | 4.09E−09 | 9.03E−07 | |Oxct1|Cd36|Ldha|Stat1|Mapt|Bdh1|Acsl4|Nqo1|Gnpat|Adipoq|Ddit3|Tfrc|A2m|Acsl1| | 8 |
GO:0,045,944 | positive regulation of transcription from RNA polymerase II promoter | 1.32E−08 | 2.60E−06 | |Lum|Mavs|Bex1|Cytl1|Scx|Pbx1|Klf2|Ablim1|Cbfa2t3|Sox4|Cbfb|Vgll2|Thrb|Esrra|Adrb2|Ppargc1b|Tp63|Hoxa5|Ddit3|Eya1|Myocd|Bmp6|Nfix|Cd28|Srebf1|Stat1|Crem|Pparg|Rxrg|Mlxipl|Ppara|Lrp5| | 9 |
GO:0,043,065 | Positive regulation of apoptotic process | 4.44E−08 | 7.67E−06 | |Dffa|Kcnma1|Tspo|Bid|G0s2|Casp3|Adamtsl4|Sfrp4|Rps6ka2|Srpx|Mllt11|Sox4|Jak2|Adrb2|Tsc22d1|Ldha|Ddit3|Trim35| | 10 |
