Table 4 Core pathways identified from pathway network analysis (in order of decreasing degree-value).

20

Citrate cycle (TCA cycle)

4

7

11

Down

1

620

Pyruvate metabolism

5

5

10

Down|up

2

4010

MAPK signalling pathway

3

7

10

Up|down

3

71

Fatty acid degradation

4

5

9

Down|up

4

640

Propanoate metabolism

5

4

9

Down|up

5

4210

Apoptosis

1

8

9

Up|down

6

4510

Focal adhesion

5

4

9

Up|down

7

72

Synthesis and degradation of ketone bodies

3

4

7

Down

8

4310

Wnt signalling pathway

4

3

7

Down|up

9

5200

Pathways in cancer

7

0

7

Up|down

10

564

Glycerophospholipid metabolism

3

3

6

Down

11

4115

p53 signalling pathway

1

5

6

Up

12

650

Butanoate metabolism

3

2

5

Down

13

3320

PPAR signalling pathway

4

1

5

Down|up

14

280

Valine, leucine, and isoleucine degradation

2

2

4

Down

15

410

beta-Alanine metabolism

2

2

4

Down

16

561

Glycerolipid metabolism

2

2

4

Down

17

630

Glyoxylate and dicarboxylate metabolism

2

2

4

Down|up

18

770

Pantothenate and CoA biosynthesis

2

2

4

Down

19

4810

Regulation of actin cytoskeleton

2

2

4

Up|down

20

5010

Alzheimer's disease

3

1

4

Up|down

21

62

Fatty acid elongation

1

2

3

Down

22

4020

Calcium signalling pathway

2

1

3

Down|up

23

4512

ECM-receptor interaction

1

2

3

Down|up

24

4920

Adipocytokine signalling pathway

1

2

3

Down|up

25

5014

Amyotrophic lateral sclerosis (ALS)

3

0

3

Up|down

26

565

Ether lipid metabolism

1

1

2

Down

27

4930

Type II diabetes mellitus

2

0

2

Down

28

310

Lysine degradation

1

0

1

Down|up

29

4530

Tight junction

1

0

1

Up|down

30

190

Oxidative phosphorylation

0

1

1

Down

31